2 edition of Nucleic acid in normal and cancer tissues found in the catalog.
Nucleic acid in normal and cancer tissues
Symposium on nucleic acid and medicine (1967 Tokyo)
|Series||Gann monographs -- 6|
Nucleic acid metabolism is concerned with the synthesis and breakdown of purine and pyrimidine nucleotides, their utilisation in DNA and RNA synthesis and the structure, localisation and function of these nucleic fixdemocracynow.com by: 4. Nucleic acid cancer biomarkers have risen to the forefront of approaches to improve cancer diagnostics, particularly in the area of point-of-care (POC) cancer diagnostics. The vast array of data from transcriptomic network studies in cancer cells versus normal cells has led to the discovery of biomarkers of various biomolecular species.
THE NUCLEIC ACID CONTENT OF FETAL RAT LIVER* BY I ) It has been shown by various investigators that embryonic tissues are richer in nucleic acid than are adult tissues (1). The distribution of the two types of nucleic acids (ribonucleic acid (RNA) and desoxy- . Oct 17, · Abstract. Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number of known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating their complex functioning molecular fixdemocracynow.com by:
Mar 14, · Protein and DNA evidences of HCMV infection in primary breast cancer tissues and metastatic sentinel lymph nodes HCMV protein and nucleic acid have been identified in a *The expression of IE2 and mRNA in breast cancer tissues and paracancerous tissues was higher than that in normal controls, and the cancer tissues were higher than Cited by: 4. In this chapter, the immense contribution of nucleic acid discovery to the diagnosis and molecular epidemiology of pathogenic microorganisms and its relevance for veterinary and human health will be discussed. The development of nucleic acid detection, amplification, and sequencing techniques, principally after the introduction of polymerase chain reaction (PCR), allowed the improvement of Cited by: 1.
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Symposium on Nucleic Acid and Medicine ( Tokyo, Japan). Nucleic acid in normal and cancer tissues. Tokyo, Maruzen, (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Katashi Makino. Add tags for "Nucleic acid in normal and cancer tissues; proceedings of the Symposium on Nucleic Acid and Medicine, Tokyo, Japan, August 17, Organizers: Katashi Makino [et al.].".
Be the first. Nucleic Acids Book. A free online book on the chemistry and biology of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab.
The Nucleic Acids of Normal Tissues and Tumors SAUL KIT* Department of Biochemistry, The University of Texas M. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Texas Enzymes, Genes, and Cancer JLwo ATTRIBUTES OF CANCER CELLS are particularly noteworthy: (1) The enzymatic and metabolic patterns are ab normal; and (2) the chromosome number and structure are Cited by: 2.
The cancer cell possesses an hereditary defect in the normal mechanism of control of cell division. Since the nucleic acids form a chemical basis of heredity in the cell it is reasonable to suspect an alteration in nucleic acids in the process of carcinogenesis.
This implies some sort of qualitative alteration in the information transfer fixdemocracynow.com by: 8.
Nucleic acids are the biopolymers, or small biomolecules, essential to all known forms of fixdemocracynow.com term nucleic acid is the overall name for DNA and RNA. They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous fixdemocracynow.com the sugar is a compound ribose, the polymer is RNA (ribonucleic acid); if the sugar is derived.
Aug 21, · Formalin-fixed paraffin embedded tissue (FFPET) represents a valuable, well-annotated substrate for molecular investigations. The utility of FFPET in molecular analysis is complicated both by heterogeneous tissue composition and low yields when extracting nucleic fixdemocracynow.com by: cancer cells is approximately twice that of the class of normal and atypical cells.
Nucleic acid content. The nucleic acid content per nucleus in resting (interphase) epithelial cells of the cervix uteri is given in Table 3. The values have been computed from the extinction at maas measured for individual nuclei and for two representations Cited by: Nucleic acid aptamers: clinical applications and promising new horizons proteins, nucleic acids, and even cells and tissues.
The term “Aptamer” is from the Latin word aptus, targeting is necessary to selectively inhibit the repair pathways in cancer cells, but not Cited by: This article provides an overview of nucleic acid-based biomarkers in tissues for the management of urologic malignancies, i.e.
tumors of the prostate, testis, kidney, penis, urinary bladder. Nucleic acid, naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid, sugars, and a mixture of organic bases (purines and pyrimidines).Nucleic acids are the main information-carrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing.
Diagnostic tests, based on nucleic acid extracts from formalin-fixed and paraffin-embedded tissues, are now becoming increasingly common due to the introduction of biological agents for cancer. Start studying Ch.5 Nucleic Acid and Cell division. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
effect on cancer on body tissues. cancer cells invade body tissues and interfere with normal functioning of the body tissues. The rationale for the design of structural analogues of a normal metabolite is that such compounds may interfere in the utilization or function of the metabolite.
A compound which is effective in this respect may be called an antimetabolite. To be successful in chemotherapy of bacterial, viral, or. DETERMINATION OF NUCLEIC ACIDS IN ANIMAL TISSUES RY GIOVANNI CERIOTTI* (From the Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, New York) (Received for publication, September 21, ) As reported in a previous paper (l), a new microchemical method for the.
Start studying Chapter 31 - Asepsis. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Oct 01, · To increase the affinity of binding to RNA targets, most ASOs are modified at the 2’ position of the ribose.
Locked nucleic acid and similar bridged nucleic acid nucleotides contain linkages between the 2’ and 4’ positions of the ribose that serve to “lock” the Cited by: 2.
“Nucleic acid medicine” is a next generation drug discovery technology with a completely different mechanism of action than traditional pharmaceutical products. It also features the ability to be manufactured easily at moderate sized molecules and the potential to exhibit efficacy and safety that surpasses those of antibody medicines.
(E) The bio-orthogonal mediated nucleic acid transfection strategy is fast and can be performed in a microfluidic format. The mixing of the keto tailored cells with the nucleic acid lipoplex for transfection occurs in less than 1 min.
The cells are then visualized after 24 h Cited by: 7. Nucleic acid blotting yields valuable information pertaining to gene integrity and copy number (Southern blot) and provides a means of analyzing gene expression and mRNA size (Northern blot).
These methods can be used to character– ize tissues and cultured cells in the laboratory and often provide valuable information for clinical evaluation Cited by: 6. Altmann, inopened the way to understanding the nature of nuclein by showing that it could be split into two substances: (1) an organic acid, rich in phosphorus, which he named nucleinic acid, later to be called nucleic acid; and (2) proteins, designated as a form of albumin.Sep 26, · During tumor development, tumor cells release their nucleic acids into the blood circulation.
This process occurs by apoptotic and necrotic cell deaths along with active cell secretion, resulting in high levels of circulating DNA, mRNA, and microRNA in the Cited by: Nucleic acid delivery for cancer holds extraordinary promise.
Increasing expression of tumor suppressor genes or inhibition of oncogenes in cancer cells has important therapeutic potential. However, several barriers impair progress in cancer gene delivery. These include effective delivery to cancer cells and relevant intracellular fixdemocracynow.com by: 7.